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The Missing Link In Heart Health Your Doctor May Not Tell You
February 17th 2021
by: Vincent Pedre M.D.

… Why Gut TMA Is Not TMI

As the “Happy Gut® Doctor,” I’ve spent a good portion of my time educating people around the world about gut health and how most health issues can be traced back to the gut. And if you’ve been following my previous blog posts, you’d know things like: how depression can actually start in the gut, because more serotonin is made in the gut than in the brain; how a leaky gut can lead to chronic inflammation, put your immune system on high alert, and even result in autoimmune disease; and how weight gain is tied to certain gut bacteria that can make it harder to lose those excess pounds.

And now this month, in honor of American Heart Health Month, I’m talking about the undeniable connection between gut health and heart disease.

Explaining the Link Between Diet & Heart Disease

While diseases like Alzheimer’s and type 2 diabetes have made a lot of headlines recently — mostly due to the sharp uptick in cases — cardiovascular disease remains the leading cause of death worldwide for both men AND women, killing more than 17.9 million people each year worldwide. We’ve known for decades that our diet influences our cardiovascular health (dietary changes have always been one of the first recommendations for issues like high cholesterol, high blood pressure, or atherosclerosis); that said, most resources tend to gloss over exactly why this connection exists and how it actually works.

This is because until not long ago, we didn’t exactly understand how this connection works. But in recent years, researchers have uncovered more details as to why the strong connection between diet and heart disease exists — and surprise! It has everything to do with the gut bacteria.

Quotation

As it turns out, the science of the gut microbiome explains why diet can affect our heart health.

Dr. Pedre Signature

Here’s what I mean: In the last few years, researchers have published several studies done on people and animals that have linked specific gut bacteria to an increased risk for heart attack and stroke. More specifically, the researchers found that when you eat certain foods that contain L-carnitine, which is found in red meat, and phosphatidylcholine, which is found in foods like eggs, cheese and shellfish, it promotes the growth of more certain gut bacteria, which then start producing higher levels of a compound called trimethylamine, or TMA. If it stopped there, it probably wouldn’t be so damaging. But the issue arises when TMA is metabolized in our livers.

Once in the body, TMA is quickly transformed by the liver into something called trimethylamine N-oxide (TMAO). And here’s where the bad news comes in: While it’s totally normal for gut bacteria to produce metabolites like TMA, the specific metabolite TMAO has been linked to cardiovascular disease risk. And it can only be produced in the liver by a process called biotransformation — in this case, by an enzyme known as flavin monooxygenase (FMO for short). Why is this important? Because people can have genetic differences in the activity of the FMO enzyme, leading to more or less conversion of TMA to TMAO.

Understanding TMAO & Heart Health

This newly discovered link isn’t a weak one, either. Studies have shown that people with higher TMAO in their blood are twice as likely to have a heart attack, stroke, or other cardiovascular emergency than those with normal TMAO levels. The results of a recent study also showed that people with high blood levels of TMAO were more likely to die prematurely. High TMAO has also been connected to heart failure and chronic kidney disease.

TMAO makes your blood clot-forming cells (aka platelets) sticky, which means it increases the likelihood they’ll stick to the inside of an artery and cause a blockage, like what happens during a heart attack or stroke.

And here’s where things get really interesting: It seems that the more red meat you eat, the more you promote the growth of “meat eating” gut bacteria in your gut and the more TMAO you end up producing when you eat meat. In contrast, vegans and vegetarians tend to have lower levels of TMAO and TMAO-producing bacteria. Talk about a vicious cycle!

Eating large and frequent amounts of red meat and animal products changes the makeup of your microbiome, causing it to produce more TMAO. #mindblown

Research has shown that about 25% of metabolites are different between omnivores and vegans and that people who adhere strictly to a plant-based diet are 25% less likely to develop heart disease. Interesting how these numbers line up, isn’t it? So while this is not a causational relationship (meaning, it’s not proven that one causes the other), it does force us to consider the idea that the changes in the gut microbiota and their metabolites are really what’s responsible for the negative effects of red meat and animal products on heart health.

Linking TMAO, Red Meat, and Saturated Fat

After reading the above, you might be scared that the next piece of advice I’ll give you is to cut out all meat, dairy, and animal-based products. Well, you can exhale because that’s not the advice I’m about to give! From my perspective, the recent learnings about red meat consumption and TMAO should encourage us to focus on eating a diet that is guided by balance and moderation.

Why? Well, research shows that those who eat a plant-rich diet have fewer TMA-producing bacteria and therefore produce less TMAO after eating animal products. In fact, vegans and vegetarians who eat meat will not initially be able to synthetize TMA in the gut or convert it to TMAO in the liver at all. It isn’t until a person continues to eat red meat regularly over a long period of time that they are able to produce these metabolites. This means that as long as you’re eating plenty of plants and only eating red meat (along with shellfish, eggs, and dairy) in moderation, your TMAO levels should stay in a healthy range. If you want to continue to enjoy red meat but want to avoid unhealthy TMAO levels, follow the five steps below.

5 Ways To Lower Your Gut TMA & Heart Disease Risk

1. Eat A Mediterranean Diet

A diet high in red meat can increase TMAO, but studies have shown that following a Meditaranean diet can help decrease it! Scientists suspect that’s because common foods in this region — like fresh fruits, vegetables, and olive oil — contain a compound called 3-dimethyl-1-butanol (DMB), which can minimize the TMAO produced from meat-eating gut microbes.

Fresh Fruits and Vegetables - Happy Gut® Blog

In fact, studies have even tested adding DMB to drinking water. I recommend focusing on fruits and vegetables since studies have also shown that fruits and vegetables are particularly important if you want to lower TMAO.

2. Make Red Meat A Treat

Red meat seems to trigger TMAO production because it contains high levels of a substance called L-carnitine. In fact, L-carnitine is actually the raw material that bacteria use to create TMA inside your gut. But let’s not give L-carnitine a bad reputation, because it’s also involved in energy metabolism. In fact, L-carnitine acts as a shuttle to transport long-chain fatty acids into the mitochondria, where they can be burned for fuel in muscles like the heart, which runs mainly on fat.
Red meat on special occasions - Happy Gut® Blog
So, instead of giving up meat entirely if you’re a meat eater, by making red meat an occasional treat — something that you have on the weekends, when you’re out, or on special occasions — while filling your body with plenty of plant-based foods, you limit the ability for your body to make TMAO and you keep the number of “meat-eating” bacteria in check. And don’t forget, the ONLY red meat you should be eating (if possible) is grass fed, in order to avoid the inflammatory omega-6 fats found in factory-raised red meat.

3. Enjoy Dairy, Eggs, & Poultry In Moderation

Studies have shown that dairy, eggs, and poultry don’t seem to have the same degree of TMA-producing capabilities as red meat and have other heart-healthy properties as well. This means that you can be less stringent on limiting these foods compared to red meat. However, if you abide by the Happy Gut® guidelines, you know dairy and eggs are not allowed during the HAPPY GUT® REBOOT: 28-Day Cleanse, until afterwards during the reintroduction phase,

Kefir grains - Happy Gut® Blog

Once you do reintroduce dairy, eggs and/or poultry, make sure you’re looking for high-quality animal-based products, like the following:

  • Organic (raw) cheese

  • Fermented milk products, like kefir or yogurt

  • Free-range, antibiotic-free, chicken, and,

  • Pasture-raised eggs

4. Watch Out For L-Carnitine-Containing Supplements & Drinks

Certain supplements and energy drinks contain ingredients like choline, phosphatidylcholine (lecithin), and/or L-carnitine, which can unknowingly cause your body to produce more TMAO. For example, one study showed that supplementing with 1000 mg/day of l-carnitine — a supplement often taken to help with energy production and fat burning — for at least 3 months led to markedly increased blood plasma TMAO levels in 7 out of 9 of the research participants with mitochondrial disorders.

Avoid Energy Drinks - Happy Gut® Blog
If you’re concerned about TMAO and trying to decrease your red meat intake, make sure to check the labels on any supplements or energy drinks you consume regularly; then, switch to alternatives if you can! This may not apply to you, however, if you don’t have a mitochondrial disorder, and more studies are needed to clarify the role supplementing with L-carnitine plays in TMAO production.

5. Exercise

Exercise has known beneficial effects on gut microbiome diversity and now, researchers suspect that exercise can actually induce changes in your microbiome composition that decrease TMA production.

It’s still unclear which type of exercise is best, so for now I recommend just breaking a sweat at least five times a week, whether that means a brisk walk, a HIIT workout, playing tennis, or even dancing. When it comes to exercise, I like to follow the saying: “The best type of exercise is the one you’ll do.” Think of it as movement therapy, and choose which type of movement you enjoy best.

Here’s the good news! At the end of the day, a Happy Gut Life is not necessarily about eliminating food groups for good — and that includes red meat. If your gut is happy, thanks to eating plenty of plants and a diverse variety of fiber-rich foods, you’ll be able to digest a wide range of foods and you won’t have to totally eliminate recipes you love off your plate forever. As a result, you can still take advantage of some of the healthy nutrients found in grass fed red meat, like B vitamins, iron, energy-shuttling L-carnitine, and zinc.

4 Comments

  1. Elena Bunnell

    Will you be offering a master class on the Heart/Gut connection?

    Reply
  2. Ann Marie

    Thanks for an interesting article but….. You use non precise words such as “large” and “frequent” when writing about amounts of red meat and “in moderation” when referring to dairy and eggs. These are pretty vague descriptions, what I consider “large” might be “very small” to someone else. “Often” to me might be “not very often” to someone else, no?
    I’d appreciate you being more specific, ie “max 3 oz of red meat per week”, or “at most 2 eggs at a time”.
    PS. I loved your interview with Marcelle Pick!!

    Reply
    • Vincent Pedre M.D.

      Thank you for this valuable feedback. I completely hear you, and will take that into account when talking about amounts.
      The truth is the results could be different for different people, depending on how many vegetables and fiber they consume
      as well. 3 oz. red meat is about right. Eggs are not as problematic, so 2 – 3 at a time, combined with greens or fiber-rich
      gluten-free bread does the trick. And moderation would mean it only once per week for red meat, whereas eggs could be twice
      or three times per week.

      Reply
  3. Elena Bunnell

    I heard that there is a Masterclass Sunday, Feb. 28 at 3 PST. Will links be sent for this? I have signed up.
    Thank you

    Reply

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